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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Epilepsia. 2014 Jan 31;55(2):233–244. doi: 10.1111/epi.12511

Figure 4. Biosensor amperometric separation of adenosine and hypoxanthene (Hx) during epileptiform events.

Figure 4

(A) Continuous fixed potential amperometry (FPA) recording over 900 seconds demonstrating 5 epileptiform events in which (1) represents a higher magnification of such an event, and (2) shows continuous spiking at the end. Note there is little variation in Hx, but adenosine consistently varies with the epileptiform activity; (B) adenosine and Hx micromolar change with event termination, 95% CI for adenosine is 1.7 to 3.4 μM and for Hx is −0.2 to 0.1. Inset shows variation in raw current (nA) of the FPA recordings. Note that there is a general decrement with null and Hx as is typical with amperometry.