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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Neurochem Int. 2013 Nov 22;73:217–228. doi: 10.1016/j.neuint.2013.11.008

Fig. 4.

Fig. 4

CHT overexpression leads to elevated tissue levels of ACh. (A) HPLC analyses of cortical, striatal, and hippocampal extracts demonstrate uniform elevations of ACh in BAC–CHT vs. WT mice Cortex, Hippocampus n = 4 (WT), 8 (BAC–CHT). Striatum n = 5 (WT), 9 (BAC–CHT) (B) Tissue choline levels were elevated in the striatum of BAC–CHT mice, but not in the cortex or hippocampus. Sample sizes are the same as in (A). (C) BAC–CHT mice show no evidence of changes in (ChAT activities Cortex: n = 8 (WT), 7 (BAC–CHT); Striatum and Hippocampus: n = 8, each genotype. (D) BAC–CHT mice show no changes in AChE activities (P > 0.05, both enzyme n = 9 each genotype, all regions). **P < 0.01, ***P < 0.001.