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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Expert Rev Mol Diagn. 2014 Feb 13;14(2):225–244. doi: 10.1586/14737159.2014.888313

Figure 2. Integrated microfluidic system for multiplexed detection of HIV and syphilis.

Figure 2

(A) Photograph of microfluidic chip. (B) Cross-section of microchannels. Scale bar, 500 µm. (C) The design of channel meanders. Scale bar, 1 mm. (D) Schematic diagram of passive fluid delivery of preloaded reagents over four detection zones based on vacuum generated by a disposable syringe. (E) Illustration of reactions at different detection steps. Signal amplification was achieved by the reduction of silver ions on gold nanoparticle-conjugated antibodies. Signals can be read quantitatively with low-cost optics or qualitatively by eyes. (F) Real-time monitoring of absorbance signals at the detection zones.

Adapted with permission from [63] © Macmillan Publishers Ltd. (2011).