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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Expert Rev Mol Diagn. 2014 Feb 13;14(2):225–244. doi: 10.1586/14737159.2014.888313

Figure 3. Integrated blood barcode chip for multiplexed detection of protein.

Figure 3

(A) Schematic of plasma separation based on Zweifach-Fung effect from a finger prick of blood. Plasma separation channels are integrated with multiple DNA-encoded antibody barcode arrays for protein detection. (B) A, B, C represent different DNA codes. (1) is the DNA-antibody conjugate, (2) is plasma protein, (3) is biotin-labeled detection antibody, (4) is streptavidin-Cy5 fluorescence probe and (5) is complementary DNA-Cy3 reference probe. The inset is a barcode of protein biomarkers with the signal measured by fluorescence detection. The green bar denotes as an alignment marker.

RBC: Red blood cells; WBC: White blood cells.

Adapted with permission from [82] © Macmillan Publishers Ltd. (2008).