Figure 9.

Spatial distribution of BrdU-positive cells and the movement in the adrenal cortex. (A) Spatial distribution of BrdU-positive cells in the adrenal cortex. □, BrdU-positive cells in the adrenal cortex from rats fed on a control diet for 10 days and sacrificed at 4:00 a.m. ■, BrdU-positive cells in the adrenal cortex from rats fed on a Na-deficient diet for 10 days and sacrificed at 8:00 p.m. In both rats, BrdU was injected at 1 h before sacrifice. (B) Behavior of BrdU-positive cells under Na-deficiency. Rats fed on a Na-deficient diet for 10 days were injected BrdU at 7:00 p.m. and sacrificed at 1 h (gray column) or at the 20th day (black column) after the injection. *P < 0.05, **P < 0.01, ***P < 0.001: data obtained at 1 h vs. at the 20th day in a comparable region. Numbers on the X-axis (relative distance from 0 edge) show the distance (cell layer) from “0”, which is defined as the position of the innermost cell layer of the undifferentiated cell zone (zU). Values are mean ± SEM. zG: zona glomerulosa, zF: zona fasciculata, zU: undifferentiated cell zone. Data from Miyamoto et al.^88,89) and Mitani et al.⁹⁰⁾