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. 2014 Aug 10;21(5):682–699. doi: 10.1089/ars.2013.5212

FIG. 5.

FIG. 5.

Effect of α-mangostin on IL-6 induced expressions of pStat3Tyr705, pStat3Ser725, pNF-κB Ser552, and proliferation of PC cells. (A) Effect of IL-6 treatment on the expression of pStat3Tyr705, pStat3Ser725, pNF-κB Ser552, total Stat3, and total NF-κB as determined by western blot analysis. (B) Effect α-mangostin on IL-6 induced expression of pStat3Tyr705, pStat3Ser725, and pNF-κB Ser552 in ASPC1 cells as determined by western blot analysis. In brief, cells were serum starved for 24 h and treated with IL-6 (50 ng/ml) for 15 min followed by α-mangostin treatment. Whole cell lysates were prepared for western blot analysis as described in the Materials and Methods section. (C) Effect of α-mangostin on IL-6-induced growth of ASPC1 and PANC1 cells as determined by MTT assay. IL-6, interleukin-6.