Table 1.
Effect of methanolic extract of P. integrifolia bark on hole cross test in rats
| Group | Dose |
Number of Movements
|
||||
|---|---|---|---|---|---|---|
| 0 min | 30 min | 60 min | 90 min | 120 min | ||
| Group-I | 10ml/kg, | 118.4 ± 1.20 | 118 ± 1.30 | 115.4 ± 0.50 | 117.4 ± 1.16 | 118 ± 0.70 |
| Group-II | 1mg/kg, | 117.2 ± 1.15 | 64.6± .43* | 40.8± .58* | 18.8± .86* | 9.6 ± 0.50* |
| Group-III | 100 mg/kg | 118.4 ± 0.81 | 70.8±1.02* | 51.8±1.35* | 36.8± .02* | 26 ± 0.71* |
| Group-IV | 200 mg/kg | 117.8 ± 1.43 | 66.8± .06* | 43.6± .92* | 26.6±0.92* | 16.6± 0.60* |
Values are mean±SEM, (n = 6);
*
p<0.05, Dunnet test as compared to vehicle control. Group I animals received vehicle (1% tween 80 in water), group II received diazepam 1 mg/kg body weight, group III and group IV were treated with 100 and 200 mg/kg body weight (p.o.) of the MEPI.