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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Hum Mutat. 2013 Aug 8;34(10):1329–1339. doi: 10.1002/humu.22380

Figure 1.

Figure 1

(A) Schematic representation of the mature IL-12Rβ1 isoforms 1 and 2. The full-length IL-12Rβ1 receptor chain, isoform 1, contains a large extracellular segment comprised of five Fibronectin type III repeat regions (FNIII). The first two FNIII repeat regions together form the cytokine-binding region (CBR) that also contains the cytokine receptor signature (WSxWS motif and two Cys-Cys pairs). The other three FNIII repeat regions are required for proper dimerization. The extracellular domain is followed by a single transmembrane domain (TM). The intracellular part contains the box 1 and box 2 cytokine receptor motifs required for JAK-associated signal transduction. Isoform 2 contains the cytokine-binding region (CBR) and one more FNIII domain followed by a stretch of 41 aa with no similarity to known domains. (B) Schematic representation of signal transduction via the IL-12 and IL-23 receptors.