Table 4.
SNPs showing a potential sex difference in association with C-reactive protein (p-heterogeneity<0.05).
Male | Female | Between sex | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Locus | SNP(coded allele) | N | Beta | SE | P-value | N | Beta | SE | P-value | P-heterogeneity |
CRP | rs1417938(A) | 3449 | −0.1 | 0.03 | 1.24E-03* | 3667 | −0.19 | 0.03 | 2.01E-09 | 0.03 |
APOE/APOC1/TOMM40 | rs4420638(G) | 9234 | −0.23 | 0.02 | 6.99E-27 | 21365 | −0.17 | 0.02 | 2.01E-26 | 0.03 |
APOE/APOC1/TOMM40 | rs429358(C) | 1012 | −0.16 | 0.04 | 1.18E-04 | 10260 | −0.27 | 0.03 | 2.96E-23 | 0.03 |
GCKR | rs1260326(T) | 10664 | 0.04 | 0.01 | 2.10E-03 | 22327 | 0.12 | 0.01 | 8.96E-23 | 1.54E-08 |
GCKR | rs780094(T) | 12095 | 0.04 | 0.01 | 2.85E-03* | 14305 | 0.12 | 0.01 | 4.74E-18 | 1.54E-08 |
HNF1A | rs2650000(A) | 11545 | −0.13 | 0.01 | 1.48E-18 | 13569 | −0.09 | 0.01 | 1.16E-10 | 0.01 |
P-values below threshold for replication (p<3.1×10−3) but not pleiotropy discovery (p<2.0×10−4).