Table 3.

Loci associated with CRP in a meta-analysis of African Americans (AA) and participants of European (Eur) descent (n=37,509).

Chr.	Most Significant	A1/ A2	Freq. (Eur)*	Beta(SE) (Eur)*	p-value (Eur)	p-value Het (Eur)	Freq. (AA)*	Beta(SE) (AA)*	p-value (AA)	p-value Het(AA)	p-value (Meta)	p-value Het(Meta)	Gene
1p31	rs1805096	G/A	0.38	−0.098(0.009)	3.3×10−30	0.013	0.45	−0.061(0.017)	2.5×10−4	0.98	5.6×10−32	0.044	LEPR
1q21	rs4129267	C/T	0.40	−0.079(0.008)	5.2×10−21	0.32	0.13	−0.12(0.025)	5.7×10−7	0.52	8.0×10−26	0.28	IL6R
1q23	rs3091244	A/G	0.62	−0.17(0.009)	3.5×10−91	0.34	0.45	−0.24(0.017)	5.1×10−45	0.11	7.8×10−132	0.011	CRP
1q44	rs12239046	C/T	0.39	−0.039(0.009)	5.3×10−6	0.93	0.51	−0.064(0.017)	1.4×10−4	0.98	7.3×10−9	0.98	NLRP3
2p23	rs1260326	C/T	0.43	0.094(0.008)	5.3×10−29	0.57	0.14	0.056(0.024)	0.019	0.63	1.0×10−29	0.57	GCKR
2q13	rs4251961	T/C	0.38	0.060(0.009)	1.4×10−12	0.37	0.18	0.081(0.022)	2.0×10−4	0.055	1.8×10−15	0.12	IL1RN
7q11	rs714052	A/G	0.12	−0.065(0.013)	3.9×10−7	0.75	0.042	−0.056(0.044)	0.20	0.80	1.7×10−7	0.91	BAZ1B
7q21	rs3211938	T/G	<0.001	−0.42(0.54)	0.44	0.96	0.085	−0.14(0.030)	1.6×10−6	0.22	1.4×10−6	0.40	CD36
11p15	rs6486121	T/C	0.37	−0.043(0.009)	6.4×10−7	0.91	0.58	−0.037(0.017)	0.026	0.098	1.3×10−7	0.57	ARNTL
12q24	rs2244608	A/G	0.34	−0.11(0.009)	4.6×10−39	0.51	0.14	−0.076(0.024)	0.0016	0.65	9.5×10−41	0.54	HNF1A
17q23	rs1292034	G/A	0.45	−0.037(0.008)	6.0×10−6	0.043	0.82	−0.039(0.02)	0.079	0.53	1.2×10−6	0.13	RPS6KB1
19q13	rs2075650	A/G	0.13	−0.18(0.012)	2.2×10−47	0.59	0.13	0.039(0.02)	0.11	0.75	1.9×10−34	1.7×10−9	TOMM40
20q13	rs1800961	C/T	0.030	−0.13(0.024)	2.0×10−7	0.63	0.0070	−0.14(0.10)	0.18	0.82	7.8×10−8	0.85	HNF4A

^*Allele frequencies and beta estimates are presented for second allele (A2).