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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2014 Apr 20;22(12):3123–3140. doi: 10.1016/j.bmc.2014.04.024

Scheme 2.

Scheme 2

Synthesis of starting lactone 11. Reagents and Conditions: (a) i. TBDPSCl, imidazole, DMF, 0°C, 51%; ii. TBDMSCl, imidazole, CH2Cl2, 0°C, 87%; (b) Allylmagnesium chloride, THF, 0 °C → rt, 89%; (c) i. BH3•SMe2 in THF, CH2Cl2, −78°C → rt; ii. PCC, CH2Cl2, rt, 74% (two steps).