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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Bioorg Med Chem. 2014 Apr 20;22(12):3123–3140. doi: 10.1016/j.bmc.2014.04.024

Scheme 3.

Scheme 3

Synthesis of regioisomeric DAG-indololactones. Reagents and Conditions: (a) i. LiHMDS, indole-aldehyde, THF, −78 °C; ii. Et3N, MsCl, DBU, CH2Cl2, 0°C → rt; (b) PPTS, EtOH, 60 °C; (c) Et3N, DMAP, (CH2CH2CH3)2CHCOCl, CH2Cl2; (d) HF•Et3N, THF, 70 °C.