Fig. 1.

Experimental time-line for Barnes maze experiments. Mice were trained on the Barnes maze, after the initial habituation trial, for 4 days with 4 trials everyday. The inter-trial interval was at least 15 min. On day 5, a single trial was performed to assess short-term retention of memory. On day 12, another single trial was performed to assess long-term memory retention and animals were randomly divided to receive saline (SAL) or kainic acid (KA) injections. On day 19, a post-KA trial was performed on the Barnes maze. Animals were not exposed to the maze between day 5 and day 12 and between day 12 and day 19.