Table 4.

Blood NGAL for the early prediction of acute kidney injury in the critical care or emergency department settings.

Reference	Patients	AKI events	AKI definition	AUC	Sensitivity (%)	Specificity (%)	Cut-off (ng/mL)	Assay
Martensson et al.62	45 adults	18	RIFLE and AKIN	0.85	83	86	>120	RIA
De Geus et al.63	632 adults	171	RIFLE F	0.86	82	70	>250	Triage®point of care  device (Biosite Inc.)
Wheeler et al.73	143 children	22	creatinine >2 mg/dL,  BUN> 100 mg/dL or  need for RRT	0.68	86	40	>140	ELISA  (Antibody Shop)
Cruz et al.74	301 adults	133	RIFLE R or worse	0.78	73	81	>150	Triage®point of care  device (Biosite Inc.)
Shapiro et al.75	661 adults	24	>0.5 mg/dL creatinine  rise or RRT within  72 h	0.82	96	51	>150	Triage®point of care  device (Biosite Inc.)
Constantin et al.76	88 adults	42	RIFLE creatinine R or  worse	0.92	82	97	>155	Triage®point of care  device (Biosite Inc.)
Royakkers et al.70	140 adults	31	RIFLE R	0.53				ELISA  (R&D Systems)
Pickering et al.77	528 adults	213	RIFLE	0.79				Triage®point of care  device (Biosite Inc.)
Soto et al.78	616 adults	130	RIFLE and AKIN	0.89	80	86	150	Triage®point of care  device (Biosite Inc.)
Total	3154	784	–	0.79	84	73	–	–

Note: For definitions see footnote of Table 1.