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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: J Control Release. 2013 Nov 12;174:88–97. doi: 10.1016/j.jconrel.2013.11.003

Scheme 1.

Scheme 1

The major species of TPT in solution in the low to neutral pH range. Two lactone forms are present (Lp and Ln) differing in the state of ionization of the phenol on ring A. Reversible hydrolysis of the ring may transform these species to their lactone E-ring may transform these species to their carboxylate counterparts (Cn and Ca respectively).