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Liposomal TPT release profiles at pH 6.33 (A) and 7.04 (B). The observed fraction of total TPT retained (
) and the resulting fit to the model described within this paper (
) are shown. The simulated profiles of the lactone (
) and ring-opened (
) forms are also displayed to illustrate the rapid depletion of the lactone. The lactone to carboxylate ratio, R (
), is also shown to highlight the role of slow carboxylate → lactone conversion during TPT release.
