TABLE III.
Bias and variability of BP estimates by four different models for simulated [18F]SPA-RQ data at different noise levels
| SRTM |
MRTM (t* = 0) |
MRTM (t* = 50) |
MRTM2 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Noise (%) | Bias (%) |
Variability (%) |
N | Bias (%) |
Variability (%) |
N | Bias (%) |
Variability (%) |
N | Bias (%) |
Variability (%) |
N |
| Striatum | ||||||||||||
| 5 | 0.2 | 4.3 | 0 | 0.2 | 4.6 | 0 | 0.9 | 7.7 | 0 | 0.2 | 3.1 | 0 |
| 10 | 1.0 | 9.3 | 0 | 1.2 | 9.4 | 0 | 3.7 | 19.1 | 0 | 0.4 | 6.2 | 0 |
| 15 | 2.2 | 15.8 | 0 | 2.6 | 15.1 | 0 | 12.4 | 45.9 | 17 | 0.2 | 9.8 | 0 |
| 20 | 4.1 | 25.6 | 0 | 5.3 | 25.0 | 0 | 14.5 | 50.6 | 51 | 1.3 | 12.1 | 0 |
| 25 | 7.7 | 41.1 | 0 | 9.6 | 38.2 | 1 | 17.2 | 62.0 | 92 | 2.5 | 17.6 | 0 |
| Prefrontal cortex | ||||||||||||
| 5 | 0.0 | 2.9 | 0 | 0.0 | 2.9 | 0 | 0.0 | 4.1 | 0 | 0.0 | 2.3 | 0 |
| 10 | 0.0 | 8.8 | 0 | 0.6 | 6.4 | 0 | 1.8 | 8.9 | 0 | 0.0 | 4.7 | 0 |
| 15 | −0.6 | 14.0 | 0 | 1.2 | 10.5 | 0 | 5.3 | 20.7 | 1 | 0.6 | 7.6 | 0 |
| 20 | −0.6 | 18.7 | 0 | 2.3 | 15.2 | 0 | 10.1 | 34.3 | 12 | 0.6 | 9.9 | 0 |
| 25 | 1.2 | 21.6 | 0 | 4.1 | 19.3 | 1 | 11.2 | 38.5 | 43 | 1.2 | 12.3 | 0 |
| Thalamus | ||||||||||||
| 5 | 0.0 | 3.5 | 0 | 0.0 | 2.7 | 0 | 0.9 | 3.6 | 0 | 0.0 | 2.6 | 0 |
| 10 | −2.7 | 10.6 | 0 | 0.0 | 6.2 | 0 | 1.8 | 7.3 | 0 | 0.0 | 4.4 | 0 |
| 15 | −3.5 | 15.0 | 0 | 0.9 | 8.8 | 0 | 4.5 | 14.5 | 5 | 0.0 | 7.0 | 0 |
| 20 | −1.8 | 14.2 | 0 | 1.8 | 12.4 | 0 | 8.2 | 31.8 | 9 | 0.0 | 8.8 | 0 |
| 25 | −0.9 | 17.7 | 0 | 3.5 | 16.8 | 0 | 9.1 | 37.3 | 16 | 0.9 | 11.4 | 0 |
Bias and variability are expressed as mean percent deviation of BP from the original value with no noise and excluded outliers. N indicates the number of outliers.