Table 1.

Predicted flux results in this study, in comparison to the experimental results in resting (healthy) state. Predictions by the original model [6] are also given for comparison.

% Flux ratio	This study	Original model	Experimental
Lactate release flux (r11) with respect to CMRglc	7.2	4.5	3–9
			[132–135]
Glutamate/glutamine cycle flux (r95) with respect to CMRglc	73.1	68.0	40–80
			[14,136,137]
Relative oxidative metabolism of astrocytes (rTCA,A/rTCA,total, r25/(r25 + r69))	33.9	35.0	30
			[136,138,139]
Total lipid synthesis with respect to CMRglc	3.1	2.8	2
			[140]
Total PPP flux with respect to CMRglc	5.5	5.6	3–6
			[141,142]
Pyruvate carboxylase flux (r12) with respect to CMRglc	11.1	11.7	10
			[136,138,143]