Figure 5.

Inhibition of agonist-induced transactivation of PPARα and PPARγ by resveratrol in HepG2 cells.

Transiently transfected HepG2 cells were incubated with increasing concentrations of resveratrol (1-100 μM) in the presence of either 10 μM Wy-14,643 (panel A) or 2 μM rosiglitazone (panel B). Twenty hours later, luciferase reporter activity was measured in cell lysates. Data represent mean ± SEM from two independent experiments, each performed in triplicate wells.