FIGURE 2.

Distinctions between the Omp85/TpsB subgroups in sequence similarities. (A) Protein–protein similarity network representation of full-length sequences, demonstrating the ten bacterial subfamilies; due to its origin from bacterial BamA the eukaryotic sequences were included to the BamA subfamily. (C) The similarity network representation of barrel-domain sequences and (E) the similarity network representation of N-terminal domain sequences, where the colors describe the different subfamilies as depicted in (A). The circled area in (E) illustrates a connected cluster consisting of proteins encoding one or more POTRA domains, whereas the sequences with alternative (non-POTRA) N-terminal domains segregate into distinct groups. (B,D,F) are a recolouring of (A,C,E), respectively, according to different bacterial Phyla (eukaryotes in gray). The color corresponding to each phylum is depicted in (B).