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Glycosphingolipid interaction with cholesterol, an important constituent of lipid rafts. (A) GalCer, extended conformation. (B,C) GalCer, tilted conformation, induced by H-bonding interactions with cholesterol OH-group, shown in (C) [(A,B): space-filling representation, (C): stick representation]. Printed with permission from Ref. (56), in an extension of earlier work by Nyholm et al. (58).
