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. 2014 Jun 23;111(28):10311–10316. doi: 10.1073/pnas.1409928111

Fig. 4.

Fig. 4.

GIA reversal assay and GIA against a heterologous parasite. (A) GIA reversal of 3D7 parasite invasion by homologous 3D7 recombinant AMA1 (2 µM) and heterologous FVO AMA1 (2 µM) when added to IgG (2mg/ mL) from PfAMA1 (blue) and PfAMA1-RON2L (red) groups. Data are mean ± SEM parasite inhibition from two independent experiments performed in duplicate. All four data points are plotted. (B) GIA of IgG from PfAMA1 (blue) and PfAMA1-RON2L (red) against heterologous FVO strain parasite. Data are mean ± SEM parasite inhibition performed at 2 mg/mL (four rats each from the AMA1 and AMA1-RON2L groups) and 5 mg/mL (three rats from the AMA1 group and four rats from the AMA1-RON2L group) performed in duplicate.