Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cytokines suppress CTSH expression. (A) Human islets were untreated or exposed to IL-1β (1 ng/mL), IFN-γ (20 ng/mL), and TNF-α (8 ng/mL) (MIX) for 24 or 48 h. CTSH was examined by microarray. Data are means ± SEMs of four individuals. (B) Purified primary rat β-cells were untreated or exposed to IL-1β (50 U/mL) and IFN-γ (500 U/mL) (MIX) for 24 h. Ctsh was examined by qPCR and normalized to Gapdh. Data are means ± SEMs (n = 6). CTRL, control. **P < 0.01; ***P < 0.001.
