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CTSH overexpression decreases cytokine signaling. INS-1 pcDNA and pCTSH cells were untreated or exposed to IL-1β (150 pg/mL) and IFN-γ (5 ng/mL) (MIX). (A–D and F) Immunoblotting was performed after stimulation for 0 h, 30 min, or 6 h. Data are means ± SEMs (n = 3–4). (E and G–I) qPCR was performed after stimulation for 2, 4, or 8 h; data are normalized to Actb and presented as fold induction. Data are means ± SEMs (n = 4). CTRL, control. *P < 0.05; **P < 0.01; ***P < 0.001.
