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. 2014 Jun 30;111(28):10305–10310. doi: 10.1073/pnas.1402571111

Fig. 5.

Fig. 5.

CTSH regulates insulin transcription and secretion. (A) Medium insulin accumulation over 24 h from INS-1 pcDNA and pCTSH cells. Data are insulin (micrograms per liter) divided by DNA content with median, SD, and 5–95 percentiles (n = 7). (B and C) INS-1 pcDNA and pCTSH cells were untreated or exposed to IL-1β (150 pg/mL) and IFN-γ (5 ng/mL) (MIX) for 24 h. Ins1 and Ins2 were examined by qPCR and normalized to Hprt1. Data are mean ± SEM (n = 4). (D) Medium insulin accumulation over 24 h from islets of WT and Ctsh−/− (KO) mice. Data are insulin (micrograms per liter) divided by DNA content with median, SD, and 5–95 percentiles (n = 4). (E) Blood glucose (milligrams per deciliter) was measured in WT and Ctsh−/− (KO) mice after overnight fasting with ad libitum water access. Median, SD, and 5–95 percentiles (n = 7 in each group). CTRL, control. **P < 0.01; ***P < 0.001.