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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Gynecol Oncol. 2014 Feb 20;133(2):370–374. doi: 10.1016/j.ygyno.2014.02.019

Table 2.

Randomized trials comparing radiotherapy vs. chemotherapy (with or without radiotherapy) in patients with stage I–IV endometrial cancer. Chemotherapy was platinum-based in all investigations. MI: myometrial invasion; RT: external beam radiotherapy; WAI: whole abdominal irradiation; OS: overall survival; PFS: progression free survival.

Author Treatment Ml >50% Stage I/II Stage IIIC Stage IV Grade 3 Residual Disease Results
Susumu; JGOG (5) RT vs. chemo 100% 35% 22% 0% 56% 0% Chemo superior OS for high intermediate risk patients
Maggi; Italy (15) RT vs. chemo 72% 78% 22% 0% 57% 0% No change in PFS or OS
Randall; GOG 122 (7) RT (WAI) vs. chemo – 0% 73% 27% 52% 16% Chemo superior OS; No change for type II or stage IIIC
Hogberg; NSGO, MaNGO (6) RT vs. RT + chemo – 55% 45% 0% 50% 0% RT + chemo superior DSS: No change for type II