Figure 1. Simple carrier model for the mechanism of glucose transport.
Co and Ci represent the transporter in the outward and inward-facing conformations, respectively, G is glucose, and a–h are the fundamental rate constants governing the conformational changes or the glucose binding and release steps. Estimates for rate constants c,d,g, and h at 20° C were calculated from the data of Lowe and Walmsley (Lowe and Walmsley, 1989).