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Diminished relation of insula activity to investment level is not attributable to medication status or income level in BPD trustees. ROI analyses within subsamples of BPD trustees were performed as described in Fig. 3. The systematic negative relation of investment level to bilateral anterior insula activity seen in healthy controls is absent in both medicated and unmedicated BPD trustees, as well as in BPD trustees matched to the income level of the control group.
