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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Drug Metab Dispos. 2006 Dec 28;35(3):428–439. doi: 10.1124/dmd.106.012641

Fig. 1.

Fig. 1

CAR2 transactivation potential is greatly enhanced by RxRα. Transfection assays were performed in COS-1 or HepG2 cells with plasmids indicated/illustrated in the figure and as described under Materials and Methods. Experiments were performed in the presence or absence of cotransfected RxRα. Data are presented as normalized and adjusted luciferase values in which the activity of the 3.1 (or RxRα)/CMV2 group is adjusted to 1 for each respective response element. Each data point represents the mean (± S.D.) of four separate transfections. A, transactivation of multiple DR response elements by CAR1 and CAR2 in the presence and absence of RxRα in COS-1 cells. B, transactivation of multiple endogenous response elements by CAR1 and CAR2 in the presence and absence of RxRα in COS-1 cells. C, transactivation of multiple endogenous response elements by CAR1 and CAR2 in the presence and absence of RxRα in HepG2 cells.