Table 1. Univariate analysis of independent variables and methylation status of P16INK4A among the studied patients.
| Variable | P16INK4A methylation status | ||
|---|---|---|---|
| Methylated | Unmethylated | p value | |
| Age (years) | p = 0.248 | ||
| < 40 years | 17 | 27 | |
| ≥ 40 years | 49 | 48 | |
| Age (years) | 43.2 ± 15.3 | 36.9 ± 13.4 | p = 0.011 |
| Active smoking | p = 0.107 | ||
| YES | 38 | 31 | |
| NO | 28 | 44 | |
| Cigarettes/day | 15.9 ± 8.8 | 14.4 ± 9.4 | p = 0.622 |
| Cigarettes/day | p = 0.394 | ||
| < 20 | 14 | 2 | |
| ≥ 20 | 11 | 5 | |
| HPV positive | p < 0.0001 | ||
| YES | 58 | 30 | |
| NO | 8 | 45 | |
| hr-HPV | p < 0.0001 | ||
| YES | 55 | 22 | |
| NO | 3 | 8 | |
| Cytology results | p < 0.0001 | ||
| Normal | 3 | 25 | |
| Altered | 63 | 50 | |