Table 3. Multivariate analysis of independent variables and methylation status of P16INK4A among the studied patients using logistic regression model.
| Variable | P16INK4A methylation status | ||
|---|---|---|---|
| Methylated (n = 66) | Unmethylated (n = 75) | p value * [OR (IC)] | |
| Age (years) | 43.2 | 36.9 | p = 0.1 |
| OR: 1.02 (0.99-1.05) | |||
| Tobacco exposure | 38 | 31 | p = 0.11 |
| OR: 1.95 (0.84-4.50) | |||
| Cigarettes/day | 15.9 | 14.4 | p = 0.1 |
| OR: 1.04 (0.76-2.74) | |||
| Presence of HPV | 66 | 30 | p < 0.0001 |
| OR: 6.04 (2.25-16.4) | |||
| hr-HPV | 55 | 22 | p = 0.01 |
| OR: 5.82 (1.95-19.3) | |||
| LSIL | 8 | 27 | p = 0.05 |
| OR: 3.82 (0.95-15.4) | |||
| HSIL | 28 | 21 | p = 0.005 |
| OR: 10.23 (2.73-38.3) | |||
| Carcinoma | 27 | 2 | p < 0.0001 |
| OR: 52.08 (10.57-72.69) | |||