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. 2014 Jan 10;136(5):2033–2039. doi: 10.1021/ja411950n

Scheme 1. Synthesis of the Nucleosidation Precursor by [4 + 2] Cycloaddition.

Scheme 1

Reagents and conditions: (a) TBDPSCl, imidazole, DMF, 20 °C, 23 h, 95%; (b) DIBAL-H, THF, −78 °C, 1 h, 95%; (c) MsCl, Et3N, CH2Cl2, −40 °C, 1 h; (d) reflux, 10 h, 74%; (e) BTCEAD, irradiate 350 nm, cyclohexane, 20 °C, 16 h, 83%.