Table 4.
Histopathological effects after sub-chronic oral ingestion (Test group, n = 7)
| Organism Code |
Histopathological effects (Number of affected animals/Degree of damage) |
||||
|---|---|---|---|---|---|
| Liver | Kidney | Spleen | Intestine | Stomach | |
| Control |
No observable histopathological changes |
No observable histopathological changes |
No observable histopathological changes |
No observable histopathological changes |
No observable histopathological changes |
| A246A |
Essentially unremarkable normal cells (2/-) Infiltration by parenchyma cells (5/+) |
Essentially unremarkable normal cells (2/-) Infiltration of tubule interstitial (5/+) |
Destruction of the normal architecture (7/+) |
Essentially unremarkable normal cells (1/-) Infiltration by inflammatory cells (6/+) |
Essentially unremarkable normal cells (2/-) Coagulative necrosis (5/+) |
| A80A |
Infiltration of portal tract by chronic inflammatory cells and congestion of blood vessel (7/+) |
Inflammation (3/+) Infiltration of tubule interstitial (4/++) |
Stroma fibrosis with dilatation of cyanocil (7/+++) |
Essentially unremarkable normal cells (1/-) Coagulative necrosis of the gland (6/++) |
Tubular necrosis (3/++) Acute necrotizing inflammation (4/+) |
| A245A | Aggregation (1/+) Congestion (3/++) Multinucleated hepatocytes (3/++) | Essentially unremarkable normal cells (1/+) Necrosis (4/++) Infiltration of tubule interstitial (2/++) | Coagulative necrosis (2/++) Destruction of the architecture (5/+++) | Coagulative necrosis (3/+) Coagulative necrosis with reactive glandula dysplacia (4/++) | Tubular necrosis (1/++) Coagulative necrosis (6/++) |
- = no observable effect, + = observable effect, ++ = clear histopatholigical damage, +++ = severe damage.