Table 3.
Pooled ORs and 95% CIs of stratified meta-analysis
| Subgroup | Genotype | No of studies |
Test of association |
Test of heterogeneity |
||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Z | P-value | Model | P-value | I 2 (%) | |||
|
Ethnicity | ||||||||
| African | ||||||||
| |
C1C2 + C2C2 vs. C1C1 |
3 |
1.92 [0.63,1.90] |
1.14 |
0.253 |
F |
0.754 |
0.0 |
| |
C2 vs. C1 |
3 |
1.15 [0.50,2.66] |
0.33 |
0.741 |
F |
0.254 |
26.9 |
| Caucasian | ||||||||
| |
C1C2 vs. C1C1 |
9 |
1.95 [1.34,2.86]* |
3.48 |
0.001 |
R |
0.016 |
57.3 |
| |
C2C2 vs. C1C1 |
9 |
1.50 [0.79,2.84] |
1.25 |
0.211 |
F |
0.341 |
11.2 |
| |
C1C2 + C2C2 vs. C1C1 |
9 |
1.68 [1.18,2.38]* |
2.87 |
0.004 |
R |
0.000 |
69.9 |
| |
C2C2 vs. C1C2 + C1C1 |
9 |
1.36 [0.71,2.58] |
0.93 |
0.354 |
F |
0.443 |
0.0 |
| |
C2 vs. C1 |
14 |
1.52 [1.14,2.02]* |
2.87 |
0.004 |
R |
0.000 |
74.8 |
| Hispanic | ||||||||
| |
C1C2 vs. C1C1 |
3 |
1.02 [0.72,1.43] |
0.08 |
0.935 |
F |
0.594 |
0.0 |
| |
C2C2 vs. C1C1 |
3 |
1.44 [0.27,7.67] |
0.42 |
0.672 |
F |
0.669 |
0.0 |
| |
C1C2 + C2C2 vs. C1C1 |
4 |
1.04 [0.76,1.44] |
0.27 |
0.789 |
F |
0.792 |
0.0 |
| |
C2C2 vs. C1C2 + C1C1 |
3 |
1.40 [0.26,7.46] |
0.4 |
0.692 |
F |
0.663 |
0.0 |
| |
C2 vs. C1 |
3 |
1.04 [0.75,1.44] |
0.23 |
0.816 |
F |
0.608 |
0.0 |
|
Disease | ||||||||
| CP | ||||||||
| |
C1C2 vs. C1C1 |
3 |
1.54 [1.04,2.27]* |
2.14 |
0.032 |
F |
0.215 |
34.9 |
| |
C2C2 vs. C1C1 |
3 |
1.32 [0.35,5.00] |
0.40 |
0.687 |
F |
0.478 |
0.0 |
| |
C1C2 + C2C2 vs. C1C1 |
5 |
1.45 [1.10,1.91] |
2.61 |
0.009 |
F |
0.281 |
21.0 |
| |
C2C2 vs. C1C2 + C1C1 |
3 |
1.26 [0.33,4.78] |
0.33 |
0.738 |
F |
0.496 |
0.0 |
| |
C2 vs. C1 |
8 |
1.38 [1.10,1.73]* |
2.82 |
0.005 |
F |
0.226 |
25.4 |
| CL/P | ||||||||
| |
C1C2 vs. C1C1 |
12 |
1.60 [1.16,2.20]* |
2.89 |
0.004 |
R |
0.010 |
55.7 |
| |
C2C2 vs. C1C1 |
11 |
1.64 [0.88,3.04] |
1.57 |
0.116 |
F |
0.457 |
0.0 |
| |
C1C2 + C2C2 vs. C1C1 |
11 |
1.46 [1.09,1.95]* |
2.55 |
0.011 |
R |
0.001 |
62.7 |
| |
C2C2 vs. C1C2 + C1C1 |
11 |
1.45 [0.82,2.78] |
1.25 |
0.211 |
F |
0.545 |
0.0 |
| |
C2 vs. C1 |
17 |
1.29 [1.01,1.66]* |
2.03 |
0.042 |
R |
0.000 |
63.1 |
|
Source of control | ||||||||
| HB | ||||||||
| |
C1C2 vs. C1C1 |
10 |
1.84 [1.32,2.56]* |
3.58 |
0.000 |
R |
0.019 |
54.7 |
| |
C2C2 vs. C1C1 |
10 |
2.96 [1.35,2.70]* |
4.70 |
0.000 |
F |
0.965 |
0.0 |
| |
C1C2 + C2C2 vs. C1C1 |
10 |
1.99 [1.35,2.70]* |
3.66 |
0.000 |
R |
0.007 |
60.1 |
| |
C2C2 vs. C1C2 + C1C1 |
10 |
2.38 [1.06,5.55]* |
5.17 |
0.000 |
F |
0.968 |
0.0 |
| |
C2 vs. C1 |
14 |
1.63 [1.22,2.18]* |
3.28 |
0.001 |
R |
0.001 |
63.0 |
| PB | ||||||||
| |
C1C2 + C2C2 vs. C1C1 |
3 |
0.99 [0.79,1.24] |
0.10 |
0.917 |
F |
0.549 |
0.0 |
| C2 vs. C1 | 3 | 1.00 [0.83,1.20] | 0.02 | 0.986 | F | 0.778 | 0.0 | |
*OR had statistical significance with corresponding 95% CI not including 1. F: Fixed effect model; R: Random effect model.