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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biomaterials. 2014 May 16;35(25):6787–6796. doi: 10.1016/j.biomaterials.2014.04.083

Fig. 3. Phase 2 and 3 Experimental Designs.

Fig. 3

A fibrocartilage defect model was formed by press fitting 3 mm punches of 6-wk-old neofibrocartilage into same-size native fibrocartilage defects and grown either in vitro or in vivo for an additional 6 wk (A). Control (none), LOX, C-ABC+TGF-β1, or LOX+C-ABC+TGF-β1 pre-treatments were applied to neofibrocartilage prior to integration assembly formation and in vitro culture in Phase 2 (B). Control (none), single LOX+C-ABC+TGF-β1, or double LOX+C-ABC+ TGF-β1 pre-treatments were applied to neofibrocartilage prior to integration assembly formation and in vivo culture in the backs of athymic mice in Phase 3 (C).