Table 1. Clinical characteristics of the study subjects.
| Case No. | Age /Sex | Tumor location (T stage*) | Cp | Initial treatment | Response to treatment† | Response to Doxycycline | Follow-up-(month) |
|---|---|---|---|---|---|---|---|
| P1 |
64/F |
Lacrimal gland (2b) |
+ |
Doxy |
CR |
Yes |
13 |
| P2 |
39/F |
Conjunctiva (1b) |
+ |
Doxy |
CR |
Yes |
24 |
| P3 |
43/M |
Orbit (2c) |
+ |
Doxy |
SD |
No |
17 |
| P4 |
51/M |
Conjunctiva (1b) |
+ |
Doxy |
PD |
No |
36 |
| P5 |
53/F |
Conjunctiva and orbit (2a) |
+ |
Doxy |
SD |
No |
20 |
| P6 |
29/F |
Conjunctiva (1b) |
+ |
Doxy |
- |
4 |
|
| N1 |
29/F |
Conjunctiva (1b) |
- |
Doxy |
CR |
Yes |
34 |
| N2 |
49/M |
Orbit (2c) |
- |
Doxy |
SD |
No |
15 |
| N3 |
79/F |
Conjunctiva (1b) |
- |
Doxy |
PR |
Yes |
15 |
| N4 |
48/M |
Orbit and eyelid (3) |
- |
RT |
CR |
- |
4 |
| N5 |
68/F |
Orbit (2c) |
- |
- |
- |
- |
- |
| N6 | 30/F | Conjunctiva (1b) | - | Doxy | - | - | - |
* American Joint Committee on Cancer staging [18] † The response to the therapy was assessed 9 weeks after the first-dose, then every 3 months for 2 years, and then every 6 months afterward, using modified international workshop criteria [19] Cp, Chlamydophila psittaci; Doxy, doxycycline; RT, radiation therapy; CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.