Table 1. Characteristics of studies included in this meta-analysis.
| First author | Year | Ethnicity (country) | SS(case/control) |
Genotypes distribution (case/control) |
HWE |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ε2/ε2 | ε2/ε3 | ε2/ε4 | ε3/ε3 | ε3/ε4 | ε4/ε4 | ε2 | ε3 | ε4 | P-value (control) | ||||
| Huiping Yuan [26] |
2007 |
Asian(China) |
36/57 |
0/0 |
0/6 |
6/12 |
12/31 |
15/8 |
3/0 |
6/18 |
39/76 |
27/20 |
<0.001 |
| Li Yun Jia [27] |
2009 |
Asian(China) |
176/200 |
2/1 |
25/29 |
5/4 |
112/136 |
29/28 |
3/2 |
34/35 |
280/329 |
38/36 |
0.964 |
| Ching Yan Lam [28] |
2006 |
Asian(China) |
400/300 |
0/0 |
74/42 |
5/8 |
280/203 |
40/47 |
1/0 |
79/50 |
674/495 |
47/55 |
0.124 |
| Fumihiko Mabuchi [29] |
2005 |
Asian(Japan) |
310/179 |
0/0 |
14/18 |
2/0 |
259/123 |
35/38 |
0/0 |
16/18 |
567/302 |
37/38 |
0.188 |
| Yijun Hu [30] |
2007 |
Asian(China) |
142/77 |
1/0 |
11/11 |
4/0 |
95/52 |
28/14 |
3/0 |
17/11 |
229/129 |
38/14 |
0.576 |
| A Jünemann [31] |
2003 |
Caucasian(Germany) |
96/32 |
0/0 |
18/3 |
1/6 |
51/14 |
26/9 |
0/0 |
19/9 |
146/40 |
27/15 |
0.027 |
| E. Saglar [32] |
2009 |
Caucasian(Turkey) |
75/119 |
0/0 |
12/9 |
1/1 |
53/88 |
8/19 |
1/2 |
13/10 |
126/204 |
11/24 |
0.929 |
| Madeleine Zetterberg [33] |
2007 |
Caucasian(Estonia) |
242/187 |
1/2 |
42/34 |
6/4 |
145/110 |
44/35 |
4/2 |
50/42 |
376/289 |
58/43 |
0.976 |
| Al-Dabbagh [34] |
2009 |
Caucasian(Saudi-Arabia) |
60/130 |
0/0 |
0/0 |
0/0 |
50/119 |
7/11 |
3/0 |
0/0 |
107/249 |
13/11 |
NA |
| James C. Vickers [35] |
2002 |
Caucasian(Tasmania) |
142/51 |
6/2 |
8/9 |
7/2 |
78/30 |
42/6 |
1/2 |
27/15 |
208/75 |
51/12 |
0.328 |
| S Lake [36] |
2004 |
Caucasian(America) |
155/349 |
1/3 |
16/37 |
10/13 |
91/208 |
31/81 |
6/7 |
28/56 |
229/534 |
53/108 |
0.472 |
| Thomas Ressiniotis [37] | 2004 | Caucasian(England) | 137/75 | −/− | −/− | −/− | −/− | −/− | −/− | 35/16 | 199/114 | 40/20 | NA |
SS: sample size. −/−: Ressiniotis et al. only provided the frequencies of APOE alleles, the frequencies of APOE genotypes could not be calculated. HWE: Hardy–Weinberg equilibrium; NA: not available.