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. Author manuscript; available in PMC: 2014 Dec 3.
Published in final edited form as: Cell Metab. 2013 Dec 3;18(6):920–933. doi: 10.1016/j.cmet.2013.11.013

Figure 4. Fatty acid β-oxidation and ketone body synthesis are highly targeted by SIRT5.

Figure 4

(A, B) Pathway analysis of succinylation (A) and SIRT5 targets (B) with the number of proteins identified per pathway. Fatty acid β-oxidation and ketone body synthesis are highlighted in blue. (C) Schematic depicting the core machinery of fatty acid β-oxidation and ketone body synthesis with SIRT5 target sites indicated on each protein. (D) Succinylation profiles of enzymes involved in fatty acid β-oxidation and ketone body synthesis. KO:WT ratio of each SuK site is shown in scatter plots. Red horizontal bar represents the median KO:WT ratio of all SuK sites on each protein. Dotted line indicates a KO:WT ratio of 2.

Abbreviations include very long chain acyl-CoA dehydrogenase (ACADV), long chain acyl-CoA dehydrogenase (ACADL), medium chain acyl-CoA dehydrogenase (ACADM), short chain acyl-CoA dehydrogenase (ACADS), trifunctional enzyme α subunit (ECHA) and β subunit (ECHB), 2,4-dienoyl-CoA reductase (DECR), enoyl-CoA delta isomerase 1 (ECI1), short chain enoyl-CoA hydratase (ECHM), short chain 3-hydroxyacyl-CoA dehydrogenase (HCDH), acetoacetyl-CoA thiolase (THIL), 3-hydroxy-3-methylglutaryl coenzyme A synthase 2 (HMCS2), 3-hydroxy-3-methylglutarate-CoA lyase (HMGCL), and 3-hydroxybutyrate dehydrogenase (BDH).