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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Drug Chem Toxicol. 2013 Oct 7;37(2):121–129. doi: 10.3109/01480545.2013.834349

Figure 3.

Figure 3

Hypothetical scheme illustrates the effects of neonatal sepsis and pneumonia on neonatal mortality. Hyperbilirubineria caused by sepsis results in kernicterus and increases neonatal mortality. Pneumococcal infections also facilitate this. SMX-TMP treatment significantly decreases neonatal mortality by controlling sepsis and pneumonia. Green arrows and plus (+) signs represent positive or facilitatory effects. Red arrows and minus (-) signs indicate negative or inhibitory effects. Question mark (?) represents undetermined effect(s). The purple arrow represents an uncovered direct effect of SMX-TMP to cause hyperbilirubinemia and kernicterus.