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Relationship between helicity and HPLC retention times of β-peptides exhibiting antifungal MICs of 16, 32, and 128 ug/mL. β-Peptides 11, 3, and 9 contain an ACHC residue, while β-peptides 21, 20, and 17 contain a β3-hVal and β-peptides 25, 24, and 23 contain a β3-hIle in place of the ACHC. Percent helicity in 100% PBS normalized to helicity in 100% methanol was determined by circular dichroism. Error bars denote standard deviation (n = 3).
