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. 2014 May 16;9(7):1613–1621. doi: 10.1021/cb500203e

Table 1. β-Peptide Retention Time, Minimum Inhibitory Concentrations (MIC) against C. albicans, and % Hemolysis at the Antifungal MIC.

β-peptide tRa (min ± SD) MICb (μg/mL) % hemolysis at MICc ± SD
1 19.3 ± 0.1 >128 2.6 ± 0.9*
2 22.5 ± 0.2 64 3.0 ± 2.4
3 23.2 ± 0.1 32 1.1 ± 2.7
4 24.5 ± 0.2 8 2.3 ± 0.7
5 25.4 ± 0.1 8 1.6 ± 0.3
6 23.1 ± 0.2 16 0.3 ± 1.7
7 23.8 ± 0.1 16 3.0 ± 2.3
8 26.2 ± 0.2 8 36.4 ± 6.0
9 20.4 ± 0.2 128 1.4 ± 0.6
10 23.5 ± 0.1 16 9.4 ± 9.3
11 24.2 ± 0.1 16 7.5 ± 5.2
12 25.7 ± 0.1 8 37 ± 15
13 26.5 ± 0.2 8 39.8 ± 2.7
14 24.0 ± 0.2 16 9.5 ± 2.2
15 24.6 ± 0.2 16 11.6 ± 2.1
16 27.4 ± 0.2 4 72 ± 14
17 22.5 ± 0.1 128 2.8 ± 0.1
18 23.5 ± 0.1 64 0.9 ± 1.9
19 22.7 ± 0.2 128 3.2 ± 2.9
20 24.3 ± 0.2 32 8.8 ± 3.6
21 25.2 ± 0.2 16 4.2 ± 2.0
22 22.8 ± 0.2 >128 3.1 ± 4.4*
23 23.8 ± 0.1 128 4.5 ± 3.2
24 24.6 ± 0.1 32 7.2 ± 5.0
25 25.7 ± 0.2 16 7.2 ± 3.4
a

The average value obtained from three independent analytical RP-HPLC measurements.

b

The value obtained from an average of three independent experiments with triplicate measurements.

c

The average value obtained from three independent experiments with duplicate measurements.

*

Hemolysis at MIC measured at 128 μg/mL β-peptide. Active (MIC ≤ 16 μg/mL) and selective (hemolysis at MIC ≤ 20%) β-peptides are in bold font.