Table 1. β-Peptide Retention Time, Minimum Inhibitory Concentrations (MIC) against C. albicans, and % Hemolysis at the Antifungal MIC.
β-peptide | tRa (min ± SD) | MICb (μg/mL) | % hemolysis at MICc ± SD |
---|---|---|---|
1 | 19.3 ± 0.1 | >128 | 2.6 ± 0.9* |
2 | 22.5 ± 0.2 | 64 | 3.0 ± 2.4 |
3 | 23.2 ± 0.1 | 32 | 1.1 ± 2.7 |
4 | 24.5 ± 0.2 | 8 | 2.3 ± 0.7 |
5 | 25.4 ± 0.1 | 8 | 1.6 ± 0.3 |
6 | 23.1 ± 0.2 | 16 | 0.3 ± 1.7 |
7 | 23.8 ± 0.1 | 16 | 3.0 ± 2.3 |
8 | 26.2 ± 0.2 | 8 | 36.4 ± 6.0 |
9 | 20.4 ± 0.2 | 128 | 1.4 ± 0.6 |
10 | 23.5 ± 0.1 | 16 | 9.4 ± 9.3 |
11 | 24.2 ± 0.1 | 16 | 7.5 ± 5.2 |
12 | 25.7 ± 0.1 | 8 | 37 ± 15 |
13 | 26.5 ± 0.2 | 8 | 39.8 ± 2.7 |
14 | 24.0 ± 0.2 | 16 | 9.5 ± 2.2 |
15 | 24.6 ± 0.2 | 16 | 11.6 ± 2.1 |
16 | 27.4 ± 0.2 | 4 | 72 ± 14 |
17 | 22.5 ± 0.1 | 128 | 2.8 ± 0.1 |
18 | 23.5 ± 0.1 | 64 | 0.9 ± 1.9 |
19 | 22.7 ± 0.2 | 128 | 3.2 ± 2.9 |
20 | 24.3 ± 0.2 | 32 | 8.8 ± 3.6 |
21 | 25.2 ± 0.2 | 16 | 4.2 ± 2.0 |
22 | 22.8 ± 0.2 | >128 | 3.1 ± 4.4* |
23 | 23.8 ± 0.1 | 128 | 4.5 ± 3.2 |
24 | 24.6 ± 0.1 | 32 | 7.2 ± 5.0 |
25 | 25.7 ± 0.2 | 16 | 7.2 ± 3.4 |
The average value obtained from three independent analytical RP-HPLC measurements.
The value obtained from an average of three independent experiments with triplicate measurements.
The average value obtained from three independent experiments with duplicate measurements.
Hemolysis at MIC measured at 128 μg/mL β-peptide. Active (MIC ≤ 16 μg/mL) and selective (hemolysis at MIC ≤ 20%) β-peptides are in bold font.