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. Author manuscript; available in PMC: 2014 Oct 10.
Published in final edited form as: Nature. 2014 Apr 2;508(7495):199–206. doi: 10.1038/nature13185

Figure 5. Areal patterning in developing neocortex.

Figure 5

a–b. Density plot showing the location of highest expression for genes with gradient-like expression in CPo (a) or SZi (b) in each brain. c. Schematic illustrating the predominant direction of gene gradients, which follow a fronto-temporal trajectory. d. FGFR3 shows caudal enrichment in germinal zones of developing human cortex. Samples are plotted on a schematic of the prenatal cortex, with expression level indicated by circle size and color. e. Similar enrichment is seen in developing mouse cortex. f–g. CBLN2 shows rostral enrichment in CP of both human (f) and mouse (g). h. Barplot showing common rostrally- (red) and caudally- (green) enriched genes across brains for each layer. i. Heatmap representation of the top 20 rostral-enriched in the CPo shows selective enrichment in frontal lobe (F).