Table 1.

Characteristics of the stratified case-cohort study population

		LACE (n=872) Weighted %	Pathways (n=766) Weighted %	Total (n=1638) Weighted %	p-value
Age at Breast Cancer Diagnosis
	< 50	22.2	22.9	22.5	0.82
	50-64	45.2	46.5	45.9
	65+	32.6	30.7	31.5
Race/Ethnicity
	White	81.6	66.3	73.3	<0.0001
	Black/AA	5.5	6.7	6.2
	Hispanic	6.2	10.8	8.7
	Asian/PI	5.5	12.8	9.5
	Other	1.2	3.4	2.4
Education
	HS or less	26.1	16.4	20.8	<0.0001
	Some college	39.6	39.4	39.5
	College grad	15.2	25.2	20.6
	Post-college	19.0	19.0	19.0
Family History
	No	75.7	80.3	78.2	0.12
	Yes	24.3	19.7	21.8
Smoking History at Breast Cancer Diagnosis
	Never	51.9	52.7	52.3	0.92
	Past	41.7	41.5	41.6
	Current	6.4	5.8	6.0
Menopausal Status at Breast Cancer Diagnosis
	Postmenopausal	66.5	71.8	69.4	<0.0001
	Premenopausal	19.4	28.2	24.2
	Unknown	14.0	0.0	6.4
BMI
	Under/Normal	46.8	35.3	40.5	0.001
	Overweight	28.8	30.7	29.8
	Obese	24.5	34.1	29.7
AJCC Stage
	I	45.7	51.6	48.9	<0.0001
	II	51.5	37.0	43.6
	III	2.8	10.4	6.9
	IV	0.0	1.0	0.5
Tumor Size
	<2cm	62.3	65.2	63.9	0.001
	>= 2cm	37.7	31.6	34.4
	Missing	0.0	3.2	1.7
Number of Positive Nodes
	0	65.2	64.1	64.6	0.001
	1-4	27.0	24.6	25.7
	5+	7.8	7.5	7.6
	Missing	0.0	3.8	2.1
Tumor Grade
	I	19.3	23.5	21.6	0.11
	II	40.1	43.5	42.0
	III-IV	31.5	26.8	28.9
	Missing	9.1	6.1	7.5
Breast Cancer Surgery
	None	0.0	1.3	0.7	<0.0001
	Lumpectomy	50.1	62.5	56.8
	Mastectomy	49.9	36.3	42.5
Chemotherapy
	No	46.5	52.6	49.8	0.08
	Yes	53.5	47.4	50.2
Radiation
	No	38.7	66.0	53.5	<0.0001
	Yes	61.3	34.0	46.5
Hormonal Therapy
	No	22.6	27.3	25.2	0.06
	Yes	77.4	72.7	74.8
Any Comorbidity (Charlson comorbidity index)
	No	87.0	85.2	86.0	0.45
	Yes	13.0	14.8	14.0
ER Status
	Negative	18.4	16.8	17.5	0.36
	Positive	81.6	83.2	82.5
PR Status
	Negative	35.4	31.6	33.3	0.20
	Positive	64.6	68.4	66.7
Her2 Status
	Negative	83.4	87.0	85.3	0.02
	Positive	16.6	13.0	14.7