Table 3.
Risk of Breast Cancer Death by PAM50 Intrinsic Subtype
All BC Deaths n=274 | Early BC Deaths (<5 years) n=115 | Late BC Deaths (5-10 years) n=154 | ||||||||||
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PAM50 Subtype | N Events | HR | Lower 95 CI | Upper 95 CI | N Events | HR | Lower 95 CI | Upper 95 CI | N Events | HR | Lower 95 CI | Upper 95 CI |
Luminal A | 96 | ref | 23 | ref | 73 | Ref | ||||||
Luminal B | 86 | 1.77 | 1.16 | 2.70 | 35 | 2.67 | 1.46 | 4.88 | 49 | 1.47 | 0.87 | 2.48 |
Luminal B PATHWAYS | 29 | 1.42 | 0.81 | 2.47 | 26 | 3.01 | 1.55 | 5.85 | 3 | 0.43 | 0.12 | 1.49 |
Luminal B LACE | 57 | 2.03 | 1.23 | 3.35 | 9 | 2.03 | 0.86 | 4.81 | 48 | 1.74 | 1.01 | 3.01 |
HER2-E | 46 | 1.27 | 0.79 | 2.02 | 24 | 2.97 | 1.58 | 5.59 | 22 | 0.73 | 0.40 | 1.33 |
Basal-like | 46 | 1.84 | 1.12 | 3.01 | 33 | 6.23 | 3.31 | 11.73 | 13 | 0.61 | 0.30 | 1.23 |
Basal-like PATHWAYS | 25 | 4.74 | 2.64 | 8.51 | 24 | 8.60 | 4.38 | 16.88 | 1 | 0.86 | 0.11 | 6.61 |
Basal-like LACE | 21 | 1.05 | 0.58 | 1.93 | 9 | 3.63 | 1.54 | 8.56 | 12 | 0.59 | 0.29 | 1.22 |
Adjusted for age, race/ethnicity, tumor size, number of positive nodes and grade