Table 4.
Early Recurrences: Comparison of PAM50 and IHC Tumor Subtype Classifications
| Early Recurrences (n=243)
|
||||
|---|---|---|---|---|
| N Events | HR | Lower 95 CI | Upper 95 CI | |
|
PAM50 Subtype*
| ||||
| Luminal A | 61 | ref | ||
| Luminal B | 82 | 2.55 | 1.68 | 3.88 |
| HER2-E | 54 | 2.83 | 1.83 | 4.38 |
| Basal | 46 | 3.98 | 2.47 | 6.42 |
|
| ||||
|
Carey Subtype defined by IHC*
| ||||
| “luminal A” surrogate | 142 | ref | ||
| “luminal B” surrogate | 31 | 1.19 | 0.79 | 1.81 |
| Her2+/ER- | 16 | 1.37 | 0.78 | 2.38 |
| TNBC | 54 | 2.13 | 1.46 | 3.11 |
|
| ||||
|
Adapted by Prat from St. Gallens Consensus conference: Subtype defined by IHC**
| ||||
| “luminal A” surrogate | 69 | ref | ||
| “luminal B” surrogate | 104 | 1.77 | 1.22 | 2.56 |
| Her2+/ER- | 16 | 2.05 | 1.16 | 3.62 |
| TNBC | 54 | 3.25 | 2.22 | 4.77 |
*
Adjusted for age, race/ethnicity, tumor size, number of positive nodes and grade
**
Adjusted for age, race/ethnicity, tumor size, and number of positive nodes