Table 3.

Differential Expression of Mouse Genes Homologous to Human 6p21.3 Region

				Gene Expression Fold Change in MAECs
Human Gene	Mouse Gene	MHC Class	From rs3869109, bp	Prelesioned	oxPAPC	oxLDL	Wild-Type Age
HLA-B	H2-D1	I	137 453	−2.29**	−2.02*	…	…
HLA-DRA	H2-Ea	II	1 223 423	442^	…	…	…
HLA-DQA1	H2-Aa	II	1 420 987	−5.60**	…	…	…
HLA-DQB1	H2-Ab1	II	1 443 045	−10.20*	…	−2.71*	−1.95*

The human homologs of differentially expressed mouse genes are listed, along with their MHC class, distance from the previously published SNP associated with CAD in Genome Wide Association Study (GWAS) meta-analysis, and fold changes of the transcript in MAECs from prelesion aortas, oxPAPC-, or oxLDL-treated aortas, and 24-week BL6 wild-type aortas compared with 4-week endothelium. CAD indicates coronary artery disease; MAEC, mouse aortic endothelial cell; MHC, major histocompatibility complex; oxLDL, oxidized low-density lipoprotein; oxPAPC, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; and RT-qPCR, reverse transcription quantitative polymerase chain reaction.

^*P ≤0.05;

^**P≤0.01; and

^{^}extreme differential expression from very low expression at base level.