Figure 2. ROI analysis of hypometabolism stratified by APOE status.

Age- and sex-adjusted mean FDG for APOE ε4 carriers and noncarriers by region. The regions are sorted by level of significance based on unadjusted p values. The estimates assume an 80-year-old subject with PiB of 1.4 and represent the average FDG for both men and women. The first column of p values on the right side of the plot is FDR-corrected p values from a test of APOE after adjusting for age, sex, and PiB. The second column shows unadjusted p values. An asterisk is used to indicate regions in which APOE was significant at the p < 0.10 level after adjusting for age and sex but not PiB. FDG = [¹⁸F]-fluorodeoxyglucose; PiB = Pittsburgh compound B; ROI = region of interest.