Table 4.
Serum Chemistry
| Molecules ID | Control
|
Gem only
|
Bel only
|
Gem + Bel
|
t-testa | ||||
|---|---|---|---|---|---|---|---|---|---|
| AVG | SD | AVG | SD | AVG | SD | AVG | SD | ||
| ALK PHOS | 90.0 | 8.5 | 67.7 | 30.6 | 80.7 | 8.4 | 68.0 | 14.7 | NS |
| GGT | 3.7 | 1.2 | 4.7 | 0.6 | 4.7 | 0.6 | 4.7 | 0.6 | NS |
| GOT (AST) | 84.0 | 14.8 | 227.3 | 112.3 | 125.3 | 21.5 | 157.3 | 78.2 | NS |
| GPT (ALT) | 32.0 | 6.6 | 51.3 | 16.0 | 48.7 | 23.8 | 58.3 | 38.1 | NS |
| AML | 105.7 | 104.0 | 302.7 | 205.4 | 686.7 | 430.3 | 854.3 | 529.6 | NS |
| BUN | 2.0 | 0.0 | 3.1 | 1.3 | 7.7 | 4.4 | 10.5 | 7.4 | NS |
| GLUCOSE | 17.0 | 8.2 | 46.7 | 24.8 | 84.7 | 65.2 | 84.5 | 88.7 | NS |
| PHOS | 1.9 | 0.0 | 1.9 | 0.0 | 3.8 | 2.4 | 5.2 | 2.9 | NS |
| CALCIUM | 5.0 | 0.0 | 5.0 | 0.0 | 6.5 | 2.5 | 7.9 | 2.6 | NS |
| ALB | 0.1 | 0.1 | 0.5 | 0.4 | 1.5 | 0.9 | 2.1 | 1.3 | NS |
| CHOLEST | 50.0 | 0.0 | 55.3 | 6.1 | 83.7 | 48.0 | 120.0 | 60.8 | NS |
| URIC | 1.5 | 0.5 | 1.6 | 0.1 | 1.5 | 0.3 | 1.7 | 0.4 | NS |
| CK | 289.7 | 38.8 | 1145.0 | 0.0 | 732.3 | 208.7 | 951.7 | 430.1 | NS |
| CREATIN | 0.3 | 0.1 | 0.2 | 0.1 | 0.3 | 0.1 | 0.3 | 0.1 | NS |
| TBIL | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | NS |
| T PROT | 4.7 | 1.3 | 4.4 | 0.9 | 5.2 | 0.3 | 4.3 | 0.4 | NS |
| GLOB | 5.6 | 0.0 | 4.2 | 0.1 | 3.8 | 0.9 | 2.2 | 1.4 | NS |
Gem, gemcitabine; Bel, belinostat; Gem + Bel, combination of gemcitabine and belinostat; AVG, average; SD, standard deviation; ALK PHOS, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; GOT (AST), glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, amylase, blood urea nitrogen, glucose levels (unstarved), phosphate, calcium, albumin, cholesterol, uric acid, creatine kinase, creatinine, total bilirubin, total protein, globulin.
a
t-test: significant difference by t-test; P-value (*, <0.05; **, <0.001); NS, not significant.