Table 2.
Pharmacoperones for GPCRs
| GPCR | Ligands | Refs. |
|---|---|---|
| GnRHR | Antagonists | 376, 424, 432, 546 |
| AVPR2 | Both agonists and antagonists | 434, 437, 438, 440, 441 |
| Rhodopsin | Vitamin A derivatives | 446, 449–451 |
| MC4R | Antagonists and ER-targeted endogenous agonist | 94, 374, 452, 454 |
| GCGR | Antagonists | 368 |
| DP1 | Inverse agonist | 460 |
| CaSR | Allosteric modulators | 461–465 |
| LHR | Allosteric agonist | 466 |
| β1-AR | Agonists | 467 |
| MOR | Both agonists and antagonists | 468 |
| κ-opioid receptor | Both agonists and antagonists | 469, 470 |
| DOR | Both agonists and antagonists | 471 |
| V1a vasopressin receptor | Antagonist | 472 |
| V1b/V3 vasopressin receptor | Antagonist | 473 |
| Kinin B1 receptor | Antagonist | 474 |
| Adenosine A1 receptor | Both agonists and antagonists | 475 |
| Leukotriene B4 type-2 receptor | Both agonist and antagonist | 476 |
| D4 DR | Both agonist and antagonists | 477 |