Figure 2.

YRV molecular mechanisms: models based on the heterochromatin sink. Y chromosomes are colored and autosomes are in black. Only one copy of each chromosome is represented. √ means activation and û means inhibition of gene expression. A: Regulatory factors (triangles) bind on satellite DNA in the Y chromosome (blue) and are depleted at other sites of the genome. The redistribution causes global modulation of gene expression. B: Regulatory factors might bind in other positions and with different strenghts in another Y chromosome (red) leading to a differential pattern of depletion across the genome.